Contact

Start a project enquiry

Filling in the form settles half of the first call: we already know the target, the expectation and your confidentiality preference.

Preparing for the call

Let us settle the scope together

Answer six questions and see at once which work is needed, which inputs you should prepare, and which files you receive at the end.

This is not a quote. Price, timing and candidate count are agreed in the scoping call. The tool produces no scientific result or success estimate.

01 What would you like to do?

This decides which arm the work runs in.

02 Do you have a structure for the target?

Without an experimental structure the work rests on a modelled one, and the report says so explicitly.

03 Is there a surface you want engaged?

If the epitope or hotspot is known, the design is directed there.

04 Does it need to discriminate against close proteins?

Give a paralog list and an epitope conservation table is produced. That is a prediction, not measured selectivity.

05 Additional analyses

You can pick more than one.

06 Do you want experimental validation?

This item is run as a service purchase from a named external laboratory and appears as a separate line in the quote.

Project enquiry

Describe your target briefly

The fields below settle half of the first call in advance. Tick the box if you want the confidentiality process started first.

Do not share confidential sequences, unpublished structures or sensitive project files in this first enquiry. Technical detail follows an appropriate confidentiality process.

Form submission is not connected yet

The contact infrastructure (recipient address, sending domain, bot verification) is not configured yet. The send button is therefore disabled: we would rather not tell you a message was delivered and lose it.

No approved alternative contact address is published yet either. We do not invent an address; it will be added here once the owner supplies it.

The target name or UniProt ID, what you want to achieve and any delivery expectation. Please leave out confidential detail.

What happens next

  1. The enquiry reaches the team as an e-mail.
  2. If needed, the confidentiality process starts first; technical detail follows after that.
  3. In the scoping call the target, region, candidate count and included analyses are put in writing.
  4. Once the scope is settled, the quote follows.

Two things worth knowing first

How do we share confidential information?

Do not share it in the first enquiry. The form asks only for a short, non-confidential summary. Technical detail, sequences and unpublished structures are taken after an appropriate confidentiality process. You can tick the box to ask for that process first.

How do scope and price become definite?

In the scoping call we put in writing the target, the region of interest, the selectivity requirement, how many candidates will be worked on and which analyses are included. The price follows that scope as a quote; we do not publish a fixed list price.

Terms used on this page

New to the field? Start here. The explanations are deliberately short.

target
The protein you are working on — the molecule you want to engage, block or detect.
binder
A protein designed to stick to the target. Think of it as the key in a lock-and-key pair.
epitope
The specific patch on the target’s surface where you want the binding to happen.
paralog
A related protein that resembles the target. You usually want the design not to bind these by mistake.
selectivity
How well a design binds the target while leaving similar proteins alone.
UniProt
The public database of protein sequences and their basic annotations.
PDB
The public database of experimentally solved protein structures.
computational
Work done on a computer. It is not an experiment; it shows which candidate is worth testing.
molecular dynamics
Simulating how a structure moves over time — it shows whether a complex holds together.
ΔΔG
An estimate of whether a single mutation makes a protein more stable or less.
BLI / SPR
Two laboratory methods that actually measure binding — where a computational prediction gets checked.
aggregation
Protein molecules clumping together — a common problem in production.
residue
A single amino acid in the protein chain — one link in the chain.
interface
The surface where two proteins touch. Whether a design works shows up largely here.
docking
Computing how a small molecule might sit in a pocket on the target.
complex
The structure formed by two or more molecules bound together.
virtual screening
Filtering a large set of compounds on a computer to surface the most promising ones.